2024
Walters JM, Noblet HA, Chung HJ. An emerging role of STriatal-Enriched protein tyrosine Phosphatase in hyperexcitability-associated brain disorders. Neurobiol Dis. 2024 Oct 1;200:106641. doi: 10.1016/j.nbd.2024.106641. Epub 2024 Aug 17. PMID: 39159894.
Vaidya RM, Zhang J, Nall D, Lee Y, Kim EC, Ma D, Huang F, Nonaka H, Kiyonaka D, Hamachi I, Chung HJ, Selvin PR (2024). Nanoscale organization is changed in native, surface AMPARs by mouse brain region and tauopathy. bioRxiv 07.22.604547; doi: https://doi.org/10.1101/2024.07.22.604547
Zhang J, Vaidya RM, Chung HJ, Selvin PR (2024). Automatic dendritic spine segmentation in widefield fluorescence images reveal synaptic nanostructures distribution with super-resolution imaging. bioRxiv 07.15.603616; doi: https://doi.org/10.1101/2024.07.15.603616
Zhang X, Dou Z, Kim SH, Upadhyay G, Havert D, Kang S, Kazemi K, Huang KY, Aydin O, Huang R, Rahman S, Ellis-Mohr A, Noblet H, Lim KH, Chung HJ, Gritton H, Saif T, Kong H, Beggs JM, Gazzola M. Mind in Vitro’ platforms: Versatile, scalable, robust and open solutions to interfacing with living neurons. Advanced Sciences. 2024 Mar;11(11):e2306826. doi: 10.1002/advs.202306826.
Huang KY, Upadhyay G, Ahn Y, Sakakura M, Diaz GP, Cho Y, Weiss A, Huang C, Li J, Tan Y, Deng YH, Ellis-Mohr A, Dou Z, Zhang X, Kang S, Chen Q, Sweedler J, Im SG, Bashir R, Chung HJ, Popescu G, Gillette MU, Gazzola M, Kong H. Neuronal Innervation Regulates the Secretion of Neurotrophic Myokines and Exosomes from Skeletal Muscle. Proceedings of the National Academy of Sciences of the United States of America, 2024. May 7;121(19):e2313590121. doi: 10.1073/pnas.2313590121.
2023
*Tracy G, *Huang KY, *Hong YT, Ding S, Noblet H, Lim KH, Kim EC, ^Chung HJ, ^Kong H. Intracerebral Nanoparticle Transport Facilitated by Alzheimer Pathology and Age. Nano Letters, 2023 Dec 13;23(23):10971-10982. PMID: 37991895. (* Contributed equally. ^Co-corresponding author.)
***Highlighted in MCB Website https://mcb.illinois.edu/news/2024-01-05/nanoparticle-transport-across-blood-brain-barrier-increases-alzheimers-and-age
Chen X, Kandel ME, He S, Hu C, Lee YJ, Sullivan K, Tracy GC, Chung HJ, Kong HJ, Anastasio M, Popescu G. Artificial confocal microscopy for deep label-free imaging. Nature Photonics. 17, 250–258 (2023). https://doi.org/10.1038/s41566-022-01140-6
Youn Y, Lau GW, Lee YJ, Maity BK, Gouaux E, Chung HJ, and Selvin PR. Quantitative DNA-PAINT imaging of AMPA receptors in live neurons. Cell Report Methods. 2023 Feb 16;3(2):100408
2022
Jin C, Jang SS, Ge P, Chung HJ, and Selvin PR. AMPA receptor number and dynamics on a synapse-to-synapse basis during maintenance of chemical LTP. Cell Reports, Under revision. Available at SSRN: https://ssrn.com/abstract=4112547 or http://dx.doi.org/10.2139/ssrn.4112547
Baculis BC, Kesavan H, Weiss AC, Kim EH, Tracy GC, Ouyang W, Tsai N-P-, and Chung HJ. Homeostatic regulation of ERK1/2 activity and axonal Kv7.3 expression by prolonged blockade of hippocampal neuronal activity. Frontiers in Cellular Neuroscience. 2022 Jul 28;16:838419. doi: 10.3389/fncel.2022.838419.
Tracy GC, Wilton AR, Rhodes JS, Chung HJ. (2022) Heterozygous deletion of epilepsy gene KCNQ2 has negligible effects on learning and memory. Frontiers in Behavioral Neuroscience, 2022 Jul 19;16:930216. doi: 10.3389/fnbeh.2022.930216
Walters, J.M., Kim, E.C., Zhang, J., Jeong, H.G., Bajaj, A., Baculis, B., Tracy, G., Ibrahim, B., Christian-Hinman, C.A., Llano, D.A., Huesmann, G.R., Chung, H.J. (2022) Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia, 2022 Feb 21. doi: 10.1111/epi.17192
***Highlighted in Illinois News Bureau https://news.illinois.edu/view/6367/356876441
2021
Kim EC, Zhang J, Tang A, Bolton EC, Rhodes JS, Christian-Hinman CA, and Chung HJ. (2021). Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2. PNAS. Dec 2021, 118 (51) e2021265118 (2021). https://doi-org.proxy2.library.illinois.edu/10.1073/pnas.2021265118.
***Highlighted in Illinois News Bureau (https://news.illinois.edu/view/6367/1884974120) , Illinois IGB Website (https://www.igb.illinois.edu/article/gene-mutation-leads-epileptic-encephalopathy-symptoms-neuron-death-mice), and Biological Research Information Center (BRIC) in South Korea (https://www.ibric.org/myboard/read.php?id=73632&Board=hbs_treatise&idauthorid=36744&ttype=0)
Pant S, Zhang J, Kim EC, Lam K, *Chung HJ, and *Tajkhorshid E. PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel. Commun Biol 4, 1189 (2021). https://doi.org/10.1038/s42003-021-02729-3. *Co-corresponding authors.
Kandel M, Kim E, Lee YJ, Tracy G, Chung HJ, and Popescu G (2021). Multiscale assay of unlabeled neurite dynamics using phase imaging with computational specificity (PICS)”. ACS Sensors. 2021, 6, 5, 1864–1874
Urrutia J, Aguado A, Gomis-Perez C, Muguruza-Montero A, Ballesteros OR, Zhang J, Nuñez, Malo, Chung HJ, Leonardo A, Bergara A and Villarroel A (2021). An Epilepsy-Causing Mutation Leads to Co-translational Misfolding. BMC Biology. 2021 May 21;19(1):109. doi: 10.1186/s12915-021-01040-1.
2020
Le P, Vaidya R, Smith LD, Han Z, Zahid MU, Winter J, Sarkar S, Chung HJ, Perez-Pinera P, Selvin PR, and Smith AM. (2020). Optimizing quantum dot probe size for single receptor imaging. ACS Nano, 2020. Jul 28;14(7):8343-8358.
Zhang J, Kim EC, Chen CC, Procko E, Pant S, Lam K, Patel J, Choi R, Hong M, Joshi D, Bolton EC, Tajkhorshid E, and Chung HJ (2020). Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy. Scientific Reports 10, 4756 (2020). https://doi.org/10.1038/s41598-020-61697-6.
Baculis BC, Zhang J, and Chung HJ (2020). The role of Kv7 channels in Neural Plasticity and Behavior. Front Physiol. 2020 Sep 18;11:568667.
Liu J, Li F, Wang Y, Pan L, Lin P, Zhang B, Zheng Y, Xu Y, Liao H, Ko G, Fei F, Xu C, Du Y, Shin K, Kim D, Jang SS, Chung HJ, Tian H, Wang Q, Guo W, Nam JM, Chen Z, Hyeon TH, Ling D (2020). A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain. Nature Nanotechnology, 2020 Feb 10. doi:10.1038/s41565-020-0634-4
Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE (2020). Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports, 2020 Jan 15;10(1):386. PMID: 31941974
2019
Kim EC, Patel J, Zhang J, Soh H, Rhodes JS, Tzingounis A, and Chung HJ. (2019). Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive, and exploratory behaviors. Genes, Brain, and Behavior. 2019 Jul 8:e12599. PMID: 31283873.
Ballance WC, Qin EC, Chung HJ, Gillette MU, and Kong HJ (2019). Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. Biomaterials, Volume 217, October 2019, 119292. https://doi.org/10.1016/j.biomaterials.2019.119292
Le P, Lim SJ, Baculis BC, Chung HJ, Kilian KA, and Smith AM. (2019). Counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions. Nat Commun. 2019 Feb 22;10(1):909. PMID: 30796217 PMCID: PMC6385258
2018
Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta, JP, Walters J, Procko E, Tsai N-P-, and Chung HJ. (2018). Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy. Neurobiology of Disease. 2018 Oct;118:76-93. PMID: 30008368.
Kim IJ, Lee J, Oh SJ, Yoon MS, Jang SS, Holland RL, Reno ML, Hamad MN, Maeda T, Chung HJ, Chen J, Blanke SR. (2018). Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1. Cell Host Microbe. 2018, May 9;23(5):583-593.e8. PMID: 29746831.
Lee KY, Jewett KA, Chung HJ, Tsai NP. (2018). Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Human Molecular Genetics, 2018 Aug 15;27(16):2805-2816. PMID: 29771335
2017
Baculis BC*, Weiss AC*, Pang W*, Jeong HG, Lee JH, Liu DC, Tsai NP, and Chung HJ (2017). Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels. Scientific Reports, 2017 Sep 26;7(1):12313. PMID: 28951616.
Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H, and Tsai NP (2017). Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity. Human Molecular Genetics, 2017 Oct 15;26(20):3895-3908.
Jang S, Jeong H, Chung HJ (2017). Electroconvulsive seizures in rats and fractionation of their hippocampi to examine seizure-induced changes in postsynaptic density proteins. Journal of Visualized Experiments, 2017 Aug 15;(126). doi: 10.3791/56016. PMID:28829421
Zhu J, Lee KY, Jewett KA, Man H, Chung HJ, Tsai N-P- (2017). Epilepsy-associated gene Nedd4-2 mediates neuronal network activity and seizure susceptibility through AMPA receptors. PLOS Genetics, 2017 Feb 17;13(2):e1006634, PMID:28212375
2016
Vega L JC, Lee MK, Qin EC, Lee KY, Chung HJ, Leckband DE, Kong H (2016). Three dimensional conjugation of recombinant N-Cadherin to a hydrogel for in vitro anisotropic neural growth. Journal of Materials Chemistry B Materials for Biology and Medicine, 4(42):6803-6811. PMCID: PMC5423733
Jang S*, Royston SE*, Gunhee Lee#, Shuwei Wang#, and Chung HJ (2016). (*These authors contributed equally; #These authors contributed equally). Seizure-induced regulations of amyloid-beta, STEP61, and STEP61 substrates involved in hippocampal synaptic plasticity. Neural Plasticity. vol. 2016, Article ID 2123748, 13 pages, 2016. doi:10.1155/2016/2123748. PMCID: PMC4835651.
Jang S and Chung HJ (2016). Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity. vol. 2016, Article ID 7969272, 19 pages, 2016. doi:10.1155/2016/7969272.
2015
Jang S*, Royston SE*, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong H, Lombroso PJ, and Chung HJ (2015). Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity. Molecular Brain. Sep 22;8(1):55. PMCID: PMC4578242.
Lee K*, Royston SE*, Vest MO, Ley DJ, Lee S, Bolton EC, and Chung H (2015). (*These authors contributed equally). N-methyl-D-aspartate Receptors mediate Activity-dependent Down-Regulation of Potassium Channel Genes during the Expression of Homeostatic Intrinsic Plasticity. Molecular Brain. 8(1):4. PMCID: PMC4333247.
2014
Wang Y, Cai E, Rosenkranz T, Ge P, Teng KW, Lim SJ, Smith A,
Chung HJ, Sachs F, Sachs F, Green W, Gottlieb P, and Selvin PR (2014). Small Quantum Dots Conjugated to Nanobodies as Immunofluorescence Probes for Nanometric Microscopy. Bioconjugate Chemistry. 25(12):2205-11. PMCID: PMC4275168.
Cai E, Ge P, Lee SH, Jeyifous O, Wang Y, Liu Y, Wilson KM, Lim SJ, Baird MA, Stone JE, Lee KY, Davidson MW, Chung HJ, Schulten K, Smith AM, Green WN, Selvin PR. (2014). Stable small quantum dots for synaptic receptor tracking on live neurons. Angewandte Chemie, 53(46):12484-8. PMCID: PMC4240739.
Lee KY and Chung HJ (2014). NMDA receptors and L-type voltage-gated Ca2+ channels mediate the Expression of Bidirectional Homeostatic Intrinsic Plasticity in Cultured Hippocampal Neurons. Neuroscience. (277):610-23 10.1016/j.neuroscience.2014.07.038. PMID: 25086314.
Cavaretta JP*, Sherer KS*, Lee KY, Issema RS, Kim EH, and Chung HJ (2014). (*These authors contributed equally). Polarized Axonal Surface Expression of Neuronal KCNQ Potassium Channels is Regulated by Calmodulin Interaction with KCNQ2 Subunit. PLos One, 9(7):e103655. DOI:10.1371/journal.pone.0103655. PMCID: PMC4117524.
Chung HJ (2014). Role of calmodulin in neuronal Kv7/KCNQ potassium channels and epilepsy. Frontiers in Biology. 9(3):205-15.
Vega L JC, Lee MK, Jeong JH, Smith CE, Lee KY, Chung HJ, Leckband DE, Kong H. (2014). Recapitulating cell-cell adhesion using N-Cadherin biologically tethered to substrates. Biomacromolecules. 15(6):2172-9. PMID: 24773064.
2013
Hearing M, Kotecki L, Marron Fernandez de Velasco E, Fajardo-Serrano A, Chung HJ, Luján R, Wickman K. (2013). Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex. Neuron 80(1):159-70. PMCID: PMC3793643.
2000-2012
Chung HJ*, Lee HK* (2009). Constructing a road map from synapses to behaviour. Meeting on Synapses: From Molecules to Circuits & Behavior. (*These authors contributed equally to this work). EMBO Rep.,10(9):958-62. PMCID: PMC2750071.
Chung HJ*, Woo-ping Ge*, Xiang Qian, Ofer Wiser, Jan YN, and Jan LY (2009). G-protein activated inwardly rectifying potassium channels mediate depotentiation of long-term potentitation. (*These authors contributed equally to this work). Proc Natl Acad Sci U S A, 106(2): 635-40. PMCID: PMC2613041.
Chung HJ, Xiang Qian, Melissa Ehlers, Jan YN, and Jan LY (2009). Neuronal activity regulates phosphorylation-dependent surface delivery of G-protein activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A, 106(2): 629-34. PMCID: PMC2613039.
Chung HJ, Jan YN, and Jan LY (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A, 103 (23): 8870-5. PMCID: PMC1472242.
Chung HJ, Lau LF, Huang YH and Huganir RL (2004). Regulation of NMDA Receptor complex and trafficking by activity-dependent phosphorylation of NR2B subunit PDZ ligand. J Neurosci, 24(45):10248-59.
Heynen AJ, Yoon BJ, Liu CH, Chung HJ, Huganir RL and Bear MF (2003). Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation. Nat Neurosci. 6(8):854-62.
Chung HJ*, Steinberg JP*, Huganir RL, Linden DJ (2003). Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. (*These authors contributed equally to this work). Science, 300(5626):1751-5.
McDonald BJ, Chung HJ, and Huganir RL (2001). Identification of Protein Kinase C phosphorylation sites within the AMPA receptor GluR2 subunit. Neuropharmacology, 41(6):672-679.
Kim CH*, Chung HJ*, Lee H-K-, and Huganir RL (2001). Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long term-depression. (*These authors contributed equally to this work). Proc Natl Acad Sci U S A, 98(20):11725-30. PMCID: PMC58797.
Xia J, Chung HJ, Wihler C, Huganir RL, and Linden DJ (2000). Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron, 28(2):499-510.
Chung HJ, Xia J, Scannevin RH, Zhang X, and Huganir RL (2000). Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci, 20(19):7258-67.